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Publications Andexer Lab

2024
J. N. Andexer, P. Germer, Trendberichte Organische Chemie 2024: Enzymreaktionen, Nachr. Chem. 2024, 72, 49, DOI: 10.1002/nadc.20244139258.
2023
E. Abdelraheem, E. Jockmann, J. Li, S. Guenter, J. N. Andexer, P-L. Hagedoorn, U. Hanefeld, Enzymatic S-Methylation of Thiols Catalyzed by Different O-Methyltransferases, ChemCatChem 2023,
E. Jockmann, F. Subrizi, M. K. F. Mohr, E. M. Carter, P. M. Hebecker, D. Popadić, H. C. Hailes, J. N. Andexer, Expanding the Substrate Scope of N- and O-Methyltransferases from Plants for Chemoselective Alkylation, ChemCatChem 2023, DOI: 10.1002/cctc.202300930.
P. Benčić, M. Keppler, M. Kuge, D. Qiu, L. M. Schütte, M. Häner, K. Strack, H. J. Jessen, J. N. Andexer, C. Loenarz, Non-canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure, The FEBS Journal 2023, DOI 10.1111/febs.16889.
M. K. F. Mohr, R. Saleem-Batcha, N. V. Cornelissen, J. N. Andexer, Enzymatic Synthesis of L-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade, Chemistry – A European Journal 2023, DOI: 10.1002/chem.202301503.
L. Gericke, D. Mhaindarkar, L. C. Karst, S. Jahn, M. Kuge, M. K. F. Mohr, J. Gagsteiger, N. V. Cornelissen, X. Wen, S. Mordhorst, H. J. Jessen, A. Rentmeister, F. P. Seebeck, G. Layer, C. Loenarz, J. N. Andexer, Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes, ChemBioChem 2023, DOI: 10.1002/cbic.202300133.
P. Germer, W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie 2023: Enzymreaktionen, Nachr. Chem. 2023, 71, 49, DOI: 10.1002/nadc.20234135542.
2022
M. Keppler, S. Moser, H. J. Jessen, C. Held, J. N. Andexer, Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions, Beilstein J. Org. Chem. 2022, DOI: 10.3762/bjoc.18.134.
T. M. Haas, B.-J. Laventie, S. Lagies, C. Harter, I. Prucker, D. Ritz, R. Saleem-Batcha, D. Qiu, W. Hüttel, J. Andexer, B. Kammerer, U. Jenal, H. J. Jessen, Photoaffinity Capture Compounds to Profile the Magic Spot NucleotideAngew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202201731.
E. Abdelraheem, B. Thair, R. F. Varela, E. Jockmann, D. Popadić, H. C. Hailes, J. M. Ward, A. M. Iribarren, E. S. Lewkowicz, J. N. Andexer, P. Hagedoorn, U. Hanefeld, Methyltransferases: Functions and Applications,  ChemBioChem 2022, DOI: 10.1002/cbic.202200212.
A. Fries, L. Mazzaferro, P. Bisel, F. Hubrich, J. N. Andexer, M. Müller, Biosynthesis of Menaquinone in E. coli: Identification of an Elusive Isomer of SEPHCHC, ChemBiochem 2022, 23, e202200181, DOI: 10.1002/cbic.202200181.
J. Gagsteiger, S. Jahn, L. Heidinger, L. Gericke, J. N. Andexer, T. Friedrich, C. Loenarz, G. Layer, A Cobalamin-Dependent Radical SAM Enzyme Catalyzes the Unique Cα-Methylation of Glutamine in Methyl-Coenzyme M Reductase, Angew. Chem. Int. Ed. 2022, 134, e202204198, DOI: 10.1002/ange.202204198.
P. Germer, J. N. Andexer, M. Müller, Biocatalytic One-Carbon Transfer – A Review, Synthesis 2022, 54, 4401–4425, DOI: 10.1055/s-0040-1719884.
W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie 2022: Enzymreaktionen, Nachr. Chem. 2022, 70, 63, DOI: 10.1002/nadc.20224122453
2021
F. Subrizi, Y. Wang, B. Thair, D. Méndez-Sánchez, R. Roddan, M. Cárdenas-Fernández, J. Siegrist, M. Richter, J. N. Andexer, J. M. Ward, H. C. Hailes, Multienzyme One-Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids, Angewandte Chemie 2021, DOI: 10.1002/ange.202104476.
M. Becker, P. Nikel, J. N. Andexer, S. Lütz, K. Rosenthal, A Multi-Enzyme Cascade Reaction for the Production of 2’3’‑cGAMP. Biomolecules 2021, DOI: 10.3390/biom11040590.
D. Popadić, D. Mhaindarkar, M. H. N. Dang Thai, H. C. Hailes, S. Mordhorst, J. N. Andexer, A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks. RSC Chem. Biol. 2021, DOI 10.1039/D1CB00033K.
F. Hubrich, M. Müller, J. N. Andexer, Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node. Chem. Commun. 2021, DOI 10.1039/D0CC08078K.
J. N. Andexer, W. Hüttel, Trendberichte Organische Chemie 2021: Enzymreaktionen, Nachr. Chem. 2021, 69, 61, DOI: 10.1002/nadc.20214105947.
2020
R. Roddan, A. Sula, D. Méndez-Sánchez, F. Subrizi, B. R. Lichman, J. Broomfield, M. Richter, J. N. Andexer, J. M. Ward, N. H. Keep, H. C. Hailes. Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases. Commun. Chem. 2020, 3, 1–10, DOI: 10.1038/s42004-020-00416-8.
C. Jacoby, J. Krull, J. Andexer, N. Jehmlich, M. von Bergen, T. Brüls, M. Boll. Channeling C1 Metabolism toward S-Adenosylmethionine-Dependent Conversion of Estrogens to Androgens in Estrogen-Degrading Bacteria. mBio 2020, 11, DOI 10.1128/mBio.01259-20.
J. N. Andexer, A. Rentmeister. Challenging nature’s preference for methylation. Nat. Chem. 2020, 12, 791–792, DOI: 10.1038/s41557-020-0533-1.
S. Mordhorst, J. N. Andexer. Round, round we go – strategies for enzymatic cofactor regeneration. Nat. Prod. Rep. 2020, DOI: 10.1039/D0NP00004C.
W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie 2020: Enzymreaktionen, Nachr. Chem. 2020, 68, 69–70, DOI: 10.1002/nadc.20204095515.
2019
G. A. Strohmeier, A. Schwarz, J. N. Andexer, M. Winkler. Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems. J. Biotechnol. 2019, DOI 10.1016/j.jbiotec.2019.10.016.
M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss, J. N. Andexer. Chorismatases - the family is growing. Org. Biomol. Chem. 2019, 17, 2092–2098. DOI 10.1039/C8OB03038C.
S. Mordhorst, J. Singh, M. K. F. Mohr, R. Hinkelmann, M. Keppler, H. J. Jessen, J. N. Andexer. Several Polyphosphate Kinase 2 Enzymes Catalyse the Production of Adenosine 5′-Polyphosphates. ChemBioChem 2019, 20, 1019–1022, DOI: 10.1002/cbic.201800704.
S. Lüdeke, J. N. Andexer, Trendberichte Organische Chemie 2019: Enzymreaktionen, Nachr. Chem. 2019, 67, 75–77, DOI: 10.1002/nadc.20194085243.
2018
J. N. Andexer, Enzymatische Methylierung in vitro: im Kreis herum oder „nur“ geradeaus?. Biospektrum 24, 556–557 (2018), DOI: 10.1007/s12268-018-0955-0.
A. E. Parnell, S. Mordhorst, F. Kemper, M. Giurrandino, J. P. Prince, N. J. Schwarzer, A. Hofer, D. Wohlwend, H. J. Jessen, S. Gerhardt, O. Einsle, P. C. F. Oyston, J. N. Andexer and P. L. Roach. Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures. PNAS 2018, 115, 3350–3355, DOI: 10.1073/pnas.1710741115.
S. Lüdeke, J. N. Andexer, Trendberichte Organische Chemie 2017: Enzymreaktionen, Nachr. Chem. 2018, 66, 278–279, DOI: 10.1002/nadc.20184072148.
2017 S. Mordhorst, A. Maurer, D. Popadić, J. Brech, J. N. Andexer. A Flexible Polyphosphate-Driven Regeneration System for Coenzyme A Dependent Catalysis. ChemCatChem 2017, 9, 4164, DOI: doi.org/10.1002/cctc.201700848.
C. Sommer-Kamann, A. Fries, S. Mordhorst, J. N. Andexer, M. Müller. Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM. Angew. Chem. 2017, 129, 4091, DOI: 10.1002/ange.201609375.
S. Mordhorst, J. Siegrist, M. Müller, M. Richter, J. N. Andexer. Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System. Angew. Chem. Int. Ed. 2017, 156, 4037–4041, DOI: 10.1002/anie.201611038.
J. Siegrist, J. Netzer, S. Mordhorst, L. Karst, S. Gerhardt, O.Einsle, M.Richter, J. N. Andexer. Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity. FEBS Letters 2017, 591, 312–321, DOI: 10.1002/1873-3468.12530.
W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie 2016: Enzymreaktionen und katalytisch aktive Proteine, Nachr. Chem. 2017, 65, 302–304, DOI: 10.1002/nadc.20174059831.
2016 W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie: Enzymreaktionen, Nachr. Chem. 2016, 64, 289–291, DOI: 10.1002/nadc.20164047492.
2015 J. Siegrist, S. Aschwanden, S. Mordhorst, L. Thöny-Meyer, M. Richter, J. N. Andexer. Regiocomplementary O-Methylation of Catechols by Using Three-Enzyme Cascades ChemBioChem 2015, 16, 2576–2579, DOI: 10.1002/cbic.201500410.
J. N. Andexer and M.Richter. Emerging Enzymes for ATP Regeneration in Biocatalytic Processes. ChemBioChem 2015, 16, 380–386, DOI: 10.1002/cbic.201402550.
W. Hüttel, J. N. Andexer, Trendberichte Organische Chemie 2014: Enzymreaktionen, Nachr. Chem. 2015, 63, 300–303, DOI: 10.1002/nadc.201590092.
2014 F. Hubrich, M. Müller, J. N. Andexer. In vitro production and purification of isochorismate using a two-enzyme cascade. J. Biotechnol. 2014, 191, 93–98, DOI: 10.1016/j.jbiotec.2014.06.003.
J. N. Andexer, W. Hüttel. Trendberichte Organische Chemie 2013: Enzymreaktionen, Nachr. Chem. 2014, 62, 278–280, DOI: 10.1002/nadc.201490086.
N. Kandziora, J. N. Andexer, S. J. Moss, B. Wilkinson, P. F. Leadlay, F. Hahn. Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis. Chemical Science 2014, 5, 3563–3567, DOI: 10.1039/C4SC00883A.
2013 P. Juneja, F. Hubrich, K. Diederichs, W. Welte, J.N. Andexer. Mechanistic Implications for the Chorismatase FkbO Based on the Crystal Structure. J. Mol. Biol. 2013, 426, 105–115, DOI: 10.1016/j.jmb.2013.09.006.
J. Schlesier, J. Siegrist, S. Gerhardt, A. Erb, S. Blaesi, M. Richter, O. Einsle, J.N. Andexer. Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis. BMC Struct. Biol. 2013, 13, 22, DOI: 10.1186/1472-6807-13-22.
J. N. Andexer, M. Müller: Trendberichte Organische Chemie 2012: Enzymreaktionen, Nachr. Chem. 2013, 61, 286–288, DOI: 10.1002/nadc.201390087.
F. Hubrich, S. Mordhorst, J. N. Andexer. Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases. Bioorg. Med. Chem. Lett. 2013, 23, 1477–1481, DOI: 10.1016/j.bmcl.2012.12.059.
2012 J. N. Andexer, N. Staunig, T. Eggert, C. Kratky, M. Pohl, K. Gruber. Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D-structures but opposite enantioselectivities and different reaction mechanisms. ChemBioChem. 2012, 13, 1932–1939, DOI: 10.1002/cbic.201200239.
J. N. Andexer, M. Müller: Trendberichte Organische Chemie 2011: Enzymreaktionen, Nachr. Chem. 2012, 60, 294–296, DOI: 10.1002/nadc.201290119.
2011 O. Vergnolle, F. Hahn, A. Baerga-Ortiz, P. F. Leadlay, J. N. Andexer. Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation. ChemBioChem. 2011, 12, 1011–1014, DOI: 10.1002/cbic.201100011.
J. N. Andexer, S. G. Kendrew, M. Nur-e-Alam, O. Lazos, T. A. Foster, A.-S. Zimmermann, T. D. Warneck, D. Suthar, N. J. Coates, F. E. Koehn, J. S. Skotnicki, G. T. Carter, M. A. Gregory, C. J. Martin, S. J. Moss, P. F. Leadlay, B. Wilkinson. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 4776–4781, DOI: 10.1073/pnas.1015773108.
2009 J.N. Andexer, J. von Langermann, U. Kragl, M. Pohl. How to overcome limitations in biotechnological processes - examples from hydroxynitrile lyase applications. Trends Biotechnol. 2009, 27, 599–607, DOI: 10.1016/j.tibtech.2009.07.005.
J.-K. Guterl, J.N. Andexer, T. Sehl, J. von Langermann, I. Frindi-Wosch, T. Rosenkranz, J. Fitter, K. Gruber, U. Kragl, T. Eggert, M. Pohl. Uneven Twins: Comparison of two enantio¬complementary hydroxynitrile-lyases with an α/β-hydrolase fold. J. Biotechnol. 2009, 141, 166–173, DOI: 10.1016/j.jbiotec.2009.03.010.
2008 T. Eggert, S. A. Funke, J. N. Andexer, M. T. Reetz, K.-E. Jaeger. Evolution of Enantioselective Bacillus subtilis Lipase. In: S. Lutz, U. T. Bornscheuer (eds), Protein Engineering Handbook, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2008, DOI: 10.1002/9783527634026.ch17.
2007 J. Andexer, J. von Langermann, A. Mell, M. Bocola, U. Kragl, T. Eggert, M. Pohl. An R-selective Hydroxynitrile Lyase from Arabidopsis thaliana with an α/β-hydrolase fold. Angew. Chem., Int. Ed. 2007, 46, 8679–8681, DOI: 10.1002/anie.200701455.
2006 T. Eggert, J. Andexer. (R)-Hydroxynitril-Lyase aus Brassicaceen. Patent Application DE 10 2006 058 373 A1 und WO 2008 067807 A2. 2006
J. Andexer, J.-K. Guterl, M. Pohl, T. Eggert. A high-throughput screening assay for hydroxynitrile lyase activity. Chem. Commun. 2006, 40, 4201–4203, DOI: 10.1039/B607863J.