Publikationen AK Hüttel
2021 |
W. Hüttel, Echinocandins: structural diversity, biosynthesis, and development of antimycotics. Appl Microbiol Biotechnol 2021, 105, 55–66. DOI 10.1007/s00253-020-11022-y.
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2020 |
W. Hüttel, M. Müller, Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis. Nat Prod Rep 2020, DOI 10.1039/d0np00010h.
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J. N. Andexer, U. Beifuss, F. Beuerle, M. Brasholz, R. Breinbauer, M. Ernst, J. Greb, T. Gulder, W. Hüttel, S. Kath-Schorr, et al., Organische Chemie 2020, Nachr. Chem. 2020, 68, 42–72. | |
2018 | J. Mattay, S. Houwaart, W. Hüttel. Cryptic Production of trans-3-Hydroxyproline in Echinocandin B Biosynthesis, Appl. Environ. Microbiol. 2018, AEM.02370-17. |
2017 | J. Mattay, W. Hüttel. Pipecolic Acid Hydroxylases: A Monophyletic Clade among cis-Selective Bacterial Proline Hydroxylases that Discriminates l-Proline, ChemBioChem 2017, 18, 1523. |
B. F. Straub, J. Andexer, C. Arenz, U. Beifuss, F. Beuerle, M. Brasholz, R. Breinbauer, K. Ditrich, T. A. M. Gulder, W. Hüttel, et al., Organische Chemie 2016. Nachr. Chem. 2017, 65, 266–304. | |
W. Hüttel. Structural diversity in echinocandin biosynthesis: the impact of oxidation steps and approaches toward an evolutionary explanation, Zeitschrift für Naturforschung 2017, 72, 1–20. | |
2016 | A. Itzen, N. Schaschke, U. Beifuss, M. Lehmann, A. Krueger, F. Beuerle, M. O. Senge, R. Breinbauer, C. Mück-Lichtenfeld, T. J. J. Müller, et al. Organische Chemie. Organische Chemie. Nachr. Chem. 2016, 64, 255-294. |
W. Hüttel, L. Youssar, B. A. Grüning, S. Günther, K. G. Hugentobler. Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster, BMC Genomics 2016, 17, 570.
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2015 | L. S. Mazzaferro, W. Hüttel, A. Fries, M. Müller. Cytochrome P450-Catalyzed Regio- and Stereoselective Phenol Coupling of Fungal Natural Products, J. Am. Chem. Soc. 2015, 137, 12289–12295. |
2014 | S. Houwaart, L. Youssar, W. Hüttel, Pneumocandin Biosynthesis: Involvement of a trans-Selective Proline Hydroxylase, ChemBioChem 2014, 15, 2365-2369. |
J. Andexer, W. Hüttel, Trendberichte 2013: Enzymreaktionen, Nachr. Chem. 2014, 62, 278-280. | |
E. Frick, T. Spatzal, S. Gerhardt, A. Krämer, O. Einsle, W. Hüttel, Structural and Functional Characterization of 4-Hydroxyphenylpyruvate Dioxygenase from the Thermoacidophilic Archaeon Picrophilus torridus, Extremophiles 2014, 1-11. | |
W. Hüttel, J. B. Spencer, P. F. Leadlay, Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding, Beilstein J. Org. Chem. 2014, 10, 361-368. | |
2013 | L. Youssar, B. A. Grüning, S. Günther, W. Hüttel, Characterization and Phylogenetic Analysis of the Mitochondrial Genome of Glarea lozoyensis Indicates High Diversity within the Order Helotiales, PLoS ONE, 2013, 8, e74792. |
W. Hüttel, Biocatalytic Production of Chemical Building Blocks in Technical Scale with alpha-Ketoglutarate Dependent Dioxygenases, Chem. Ing. Tech. 2013, 85, 85, 809-817. | |
2012 | C. Gil Girol, W. Hüttel, S. Fögen, K. M. Fisch, J. Piel, T. Heinekamp, A. Brakhage, M. Müller. Regio- and stereoselektive intermolecular oxidative phenol coupling in filamentous fungi, Pharmaceutical Biology 2012, 50, 617. |
L. Youssar, B. A. Grüning, A. Erxleben, S. Günther, W. Hüttel, Genome sequence of the fungus Glarea lozoyensis: the First Genome Sequence of a Species from the Helotiaceae Family, Eukaryotic Cell 2012, 11, 250. | |
C. Gil Girol, K. M. Fisch, T. Heinekamp, S. Günther, W. Hüttel, J. Piel, A. A. Brakhage, M. Müller, Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger, Angew. Chem. 2012, 124, 9926–9929; Angew. Chem. Int. Ed. 2012, 51, 9788–9791. | |
2011 | C. Klein, W. Hüttel, Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases. Beilstein J. Org. Chem., 2011, 7, 1643-1647. |
C. Klein, W. Hüttel, A Simple Procedure for Selective Hydroxylation of L-Proline and L-Pipecolic Acid with Recombinantly Expressed Proline Hydroxylases, Adv. Synth. Catal. 2011, 353, 1375-1383. | |
W. Hüttel, M. Müller, Highlights 2010: Enzymreaktionen, Nachr. Chem. 2011, 59, 282-283. | |
W. Hüttel, M. Müller, Highlights 2011: Enzyme in der organischen Synthese, Nachr. Chem. 2011, 59, 282-283. | |
2010 | W. Hüttel, D. Hoffmeister, Fungal Biotransformations in Pharmaceutical Sciences, in Industrial Applications, Vol. 10 (Ed.: M. Hofrichter), Springer Berlin Heidelberg, 2010, pp. 293-317. |
2009 | M. M. Misiek, J. Williams, K. Schmich, W. Hüttel, I. Merfort, C. E. Salomon,C. C. Aldrich, D. Hoffmeister, Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters, J. Nat Prod. 2009, 72, 1888-1891. |
W. Hüttel, M. Müller, Highlights 2008: Enzyme in der organischen Synthese, Nachr. Chem. 2009, 57, 274-275. | |
2007 | D. Drochner, W. Hüttel, S. E. Bode, M. Müller, U. Karl, M. Nieger, W. Steglich, Dimeric Orsellinic Acid Derivatives: Valuable Intermediates for Natural Product Synthesis, Eur. J. Org. Chem. 2007, 1749-1758. |
W. Hüttel, M. Müller, Regio- and Stereoselective Intermolecular Oxidative Phenol Coupling in Kotanin Biosynthesis by Aspergillus niger, ChemBioChem 2007, 8, 521-529. | |
2003 | W. Hüttel, M. Nieger, M. Müller, A Short and Efficient Total Synthesis Synthesis of the Naturally Occuring Coumarins Siderin, Kotanin, Isokotanin A and Desertorin C, Synthesis 2003, 1803-1808. |
D. Drochner, W. Hüttel, M. Nieger, M. Müller, Unselective Phenolic Coupling of Methyl 2-Hydroxy-4-methoxy-6-methylbenzoate – A Valuable Tool for the Total Synthesis of Natural Product Families, Angew. Chem. 2003, 115, 961-963; Angew. Chem. Int. Ed. 2003, 42, 931-933. |