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Publikationen AK Hüttel

2021
W. Hüttel, Echinocandins: structural diversity, biosynthesis, and development of antimycotics. Appl Microbiol Biotechnol 2021, 105, 55–66. DOI 10.1007/s00253-020-11022-y.
2020
W. Hüttel, M. Müller, Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis. Nat Prod Rep 2020, DOI 10.1039/d0np00010h.
J. N. Andexer, U. Beifuss, F. Beuerle, M. Brasholz, R. Breinbauer, M. Ernst, J. Greb, T. Gulder, W. Hüttel, S. Kath-Schorr, et al., Organische Chemie 2020, Nachr. Chem. 2020, 68, 42–72.
2018 J. Mattay, S. Houwaart, W. Hüttel. Cryptic Production of trans-3-Hydroxyproline in Echinocandin B Biosynthesis, Appl. Environ. Microbiol. 2018, AEM.02370-17.
2017 J. Mattay, W. Hüttel. Pipecolic Acid Hydroxylases: A Monophyletic Clade among cis-Selective Bacterial Proline Hydroxylases that Discriminates l-Proline, ChemBioChem 2017, 18, 1523.
B. F. Straub, J. Andexer, C. Arenz, U. Beifuss, F. Beuerle, M. Brasholz, R. Breinbauer, K. Ditrich, T. A. M. Gulder, W. Hüttel, et al., Organische Chemie 2016. Nachr. Chem. 2017, 65, 266–304.
W. Hüttel. Structural diversity in echinocandin biosynthesis: the impact of oxidation steps and approaches toward an evolutionary explanation, Zeitschrift für Naturforschung 2017, 72, 1–20.
2016 A. Itzen, N. Schaschke, U. Beifuss, M. Lehmann, A. Krueger, F. Beuerle, M. O. Senge, R. Breinbauer, C. Mück-Lichtenfeld, T. J. J. Müller, et al. Organische Chemie. Organische Chemie. Nachr. Chem. 2016, 64, 255-294.
W. Hüttel, L. Youssar, B. A. Grüning, S. Günther, K. G. Hugentobler. Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster, BMC Genomics 2016, 17, 570.
2015 L. S. Mazzaferro, W. Hüttel, A. Fries, M. Müller. Cytochrome P450-Catalyzed Regio- and Stereoselective Phenol Coupling of Fungal Natural Products, J. Am. Chem. Soc. 2015, 137, 12289–12295.
2014 S. Houwaart, L. Youssar, W. Hüttel, Pneumocandin Biosynthesis: Involvement of a trans-Selective Proline Hydroxylase, ChemBioChem 2014, 15, 2365-2369.
J. Andexer, W. Hüttel, Trendberichte 2013: Enzymreaktionen, Nachr. Chem. 2014, 62, 278-280.
E. Frick, T. Spatzal, S. Gerhardt, A. Krämer, O. Einsle, W. Hüttel, Structural and Functional Characterization of 4-Hydroxyphenylpyruvate Dioxygenase from the Thermoacidophilic Archaeon Picrophilus torridus, Extremophiles  2014, 1-11.
W. Hüttel, J. B. Spencer, P. F. Leadlay, Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding, Beilstein J. Org. Chem. 2014, 10, 361-368.
2013 L. Youssar, B. A. Grüning, S. Günther, W. Hüttel, Characterization and Phylogenetic Analysis of the Mitochondrial Genome of Glarea lozoyensis Indicates High Diversity within the Order Helotiales, PLoS ONE, 2013, 8, e74792.
W. Hüttel, Biocatalytic Production of Chemical Building Blocks in Technical Scale with alpha-Ketoglutarate Dependent Dioxygenases, Chem. Ing. Tech. 2013, 85, 85, 809-817. 
2012 C. Gil Girol, W. Hüttel, S. Fögen, K. M. Fisch, J. Piel, T. Heinekamp, A. Brakhage, M. Müller. Regio- and stereoselektive intermolecular oxidative phenol coupling in filamentous fungi, Pharmaceutical Biology 2012, 50, 617.
L. Youssar, B. A. Grüning, A. Erxleben, S. Günther, W. Hüttel, Genome sequence of the fungus Glarea lozoyensis: the First Genome Sequence of a Species from the Helotiaceae Family, Eukaryotic Cell 2012, 11, 250.
C. Gil Girol, K. M. Fisch, T. Heinekamp, S. Günther, W. Hüttel, J. Piel, A. A. Brakhage, M. Müller, Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger, Angew. Chem. 2012, 124, 9926–9929; Angew. Chem. Int. Ed. 2012, 51, 9788–9791.
2011 C. Klein, W. Hüttel, Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases. Beilstein J. Org. Chem., 2011, 7, 1643-1647.
C. Klein, W. Hüttel, A Simple Procedure for Selective Hydroxylation of L-Proline and L-Pipecolic Acid with Recombinantly Expressed Proline Hydroxylases, Adv. Synth. Catal. 2011, 353, 1375-1383.
W. Hüttel, M. Müller, Highlights 2010: Enzymreaktionen, Nachr. Chem. 2011, 59, 282-283.
W. Hüttel, M. Müller, Highlights 2011: Enzyme in der organischen Synthese, Nachr. Chem. 2011, 59, 282-283.
2010 W. Hüttel, D. Hoffmeister, Fungal Biotransformations in Pharmaceutical Sciences, in Industrial Applications, Vol. 10 (Ed.: M. Hofrichter), Springer Berlin Heidelberg, 2010, pp. 293-317.
2009 M. M. Misiek, J. Williams, K. Schmich, W. Hüttel, I. Merfort, C. E. Salomon,C. C. Aldrich, D. Hoffmeister,   Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters,   J. Nat Prod. 2009, 72, 1888-1891.
W. Hüttel, M. Müller, Highlights 2008: Enzyme in der organischen Synthese, Nachr. Chem. 2009, 57, 274-275.
2007 D. Drochner, W. Hüttel, S. E. Bode, M. Müller, U. Karl, M. Nieger, W. Steglich, Dimeric Orsellinic Acid Derivatives: Valuable Intermediates for Natural Product Synthesis, Eur. J. Org. Chem. 2007, 1749-1758.
W. Hüttel, M. Müller, Regio- and Stereoselective Intermolecular Oxidative Phenol Coupling in Kotanin Biosynthesis by Aspergillus niger, ChemBioChem  2007,  8,  521-529.
2003 W. Hüttel, M. Nieger, M. Müller, A Short and Efficient Total Synthesis Synthesis of the Naturally Occuring Coumarins Siderin, Kotanin, Isokotanin A and Desertorin C, Synthesis 2003, 1803-1808.
D. Drochner, W. Hüttel, M. Nieger, M. Müller, Unselective Phenolic Coupling of Methyl 2-Hydroxy-4-methoxy-6-methylbenzoate – A Valuable Tool for the Total Synthesis of Natural Product Families, Angew. Chem. 2003, 115, 961-963; Angew. Chem. Int. Ed. 2003, 42, 931-933.