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Publikationen AK Lüdeke

2021 B. Frensch, T. Lechtenberg, M. Kather, Z. Yunt, M. Betschart, B. Kammerer, S. Lüdeke, M. Müller, J. Piel, R. Teufel, Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides. Nat. Comm. 2021, 12, 1431.
2019 G. Pescitelli, S. Lüdeke, M. Górecki, L. Di Bari, Symmetry-Dependent Vibrational Circular Dichroism Enhancement in Co(II) Salicylaldiminato Complexes. J. Phys. Chem. Lett. 2019, 10, 650–654. DOI 10.1021/acs.jpclett.8b03764.
M. Häckh, X. Lucas, M. Marolt, P. F. Leadlay, M. Müller, S. Günther, S. Lüdeke, Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure–Selectivity Relationship of a Ketoreductase. ChemBioChem 2019, 201150–1154. DOI 10.1002/cbic.201800799.
M. Marolt, S. Lüdeke, Studying NAD(P)H cofactor-binding to alcohol dehydrogenases through global analysis of circular dichroism spectra. Phys. Chem. Chem. Phys. 2019, 21, 1671–1681.


G. Pescitelli, S. Lüdeke, A.-C. Chamayou, M. Marolt, V. Justus, M. Górecki, L. Arrico, L. Di Bari, M. A. Islam, I. Gruber, et al., Broad-Range Spectral Analysis for Chiral Metal Coordination
Compounds: (Chiro)optical Superspectrum of Cobalt(II) Complexes. Inorg. Chem. 2018, 57, 13397–13408.
N. Ortlieb, K. Bretzel, A. Kulik, J. Haas, S. Lüdeke, N. Keilhofer, S. D. Schrey, H. Gross, T. H. J. Niedermeyer, Xanthocidin Derivatives from the Endophytic Streptomyces sp. AcE210 Provide Insight into the Xanthocidin Biosynthesis. ChemBioChem, DOI 10.1002/cbic.201800467.
M. Willistein, J. Haas, J. Fuchs, S. Estelmann, S. Ferlaino, M. Müller, S. Lüdeke, M. Boll, Enantioselective enzymatic naphthoyl‐ring reduction. Chem. Eur. J. 2018, 24, 12505
J. Schulz-Fincke, M. Hau, J. Barth, D. Robaa, D. Willmann, A. Kürner, J. Haas, G. Greve, T. Haydn, S. Fulda, M. Lübbert, S. Lüdeke, T. Berg., W. Sippl, R. Schüle and M. Jung. Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation. Eur. J. Med. Chem. 2018, 144, 52–67.
2017 J. Haas, M. Häckh, V. Justus, M. Müller, S. Lüdeke. Addition of a polyhistidine tag alters the regioselectivity of carbonyl reductase S1 from Candida magnoliae. Org. Biomol. Chem. 2017, 15, 10256–10264.
S. Roth, A. Präg, C. Wechsler, M. Marolt, S. Ferlaino, S. Lüdeke, N. Sandon, D. Wetzl, H. Iding, B. Wirz, and M. Müller. Extended Catalytic Scope of a Well-Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase ChemBioChem 2017, 18, 1703–1706.
M. Sarem, S. Lüdeke, R. Thomann, P. Salavei, Z. Zou, W. Habraken, A. Masic, V. P. Shastri. Disordered Conformation with Low Pii Helix in Phosphoproteins Orchestrates Biomimetic Apatite Formation. Adv. Mater. 2017, 29, 1701629.
M. Sarem, D. Vonwil, S. Lüdeke, V. P. Shastri. Direct quantification of dual protein adsorption dynamics in three dimensional systems in presence of cells. Acta Biomaterialia 2017, 57, 285–292.
A. Rüther, A. Forget, A. Roy, C. Carballo, F. Mießmer, R. K. Dukor, L. A. Nafie, C. Johannessen, V. P. Shastri, S. Lüdeke. Unravelling a Direct Role for Polysaccharide β-Strands in the Higher Order Structure of Physical Hydrogels. Angew. Chem. 2017, 129, 4674.
A. Greule, M. Marolt, D. Deubel, I. Peintner, S. Zhang, C. Jessen-Trefzer, C. De Ford, S. Burschel, S.-M. Li, T. Friedrich, I. Merfort, S. Lüdeke, P. Bisel, M. Müller, T. Paululat and A. Bechthold. Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains – An Unusual Secondary Metabolite with Various Properties. Front Microbiol 2017, 8, 221.
2016 D. Diedrich, A. J. R. Moita, A. Rüther, B. Frieg, G. J. Reiss, A. Hoeppner, T. Kurz, H. Gohlke, S. Lüdeke, M. U. Kassack, F. K. Hansen. α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers. Chem. Eur. J. 2016, 22, 17600.
C. Heering, B. Francis, B. Nateghi, G. Makhloufi, S. Lüdeke, C. Janiak. Syntheses, structures and properties of group 12 element (Zn, Cd, Hg) coordination polymers with a mixed-functional phosphonate-biphenyl-carboxylate linker. CrystEngComm 2016, 18, 5209–5223.
P. Lehwald, O. Fuchs, L. A. Nafie, M. Müller, S. Lüdeke. Substrate-Determined Diastereoselectivity in an Enzymatic Carboligation. ChemBioChem 2016, 17, 1207.
J. Haas, M. A. Schätzle, S. M. Husain, J. Schulz-Fincke, M. Jung, W. Hummel, M. Müller, S. Lüdeke. A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates. Chem. Commun. 2016, 52, 5198–5201.
2015 M. Sarem, S. Lüdeke: Circular dichroism: A powerful tool for studying biomineralization promoter proteins, MRS Bull. 2015, 40, 490–498.
A.-C. Chamayou, G. Makhloufi, L. A. Nafie, C. Janiak, S. Lüdeke: Solvation-induced helicity inversion of pseudotetrahedral chiral copper(II) complexes. Inorg Chem. 2015, 54, 2193–203.
A. Forget, R.-A. Pique, V. Ahmadi, S. Lüdeke, V. P. Shastri: Mechanically Taylored Agarose Hydrogels through Molecular Alloying with beta-Sheet Polysaccharides, Macromol. Rapid Commun. 2015, 36, 196–203.
2014 S. M. Husain, M. A. Schätzle, S. Lüdeke, M. Müller: Unprecedented Role of Hydronaphthoquinone Tautomers in Biosynthesis, Angew. Chem. Int. Ed. 2014, 53, 9806–9811; Angew. Chem. 2014, 126, 9964–9969.
A. Präg, B. A. Grüning, M. Häckh, S. Lüdeke, M. Wilde, A. Luzhetskyy, M. Richter, M. Luzhetska, S. Günther, M. Müller: Regio- and Stereoselective Intermolecular Oxidative Phenol Coupling in Streptomyces, J. Am. Chem. Soc. 2014, 136, 6195–6198.
A. Rüther, M. Pfeifer, V. A. Lórenz-Fonfría, S. Lüdeke: pH Titration Monitored by Quantum Cascade Laser-Based Vibrational Circular Dichroism, J. Phys. Chem. B 2014, 118, 3941–3949.
A. Rüther, M. Pfeifer, V. A. Lórenz-Fonfría, S. Lüdeke: Reaction monitoring using mid-infrared laser-based vibrational circular dichroism, Chirality 2014, 26, 490–496.
2013 A. Forget, J. Christensen, S. Lüdeke, E. Kohler, S. Tobias, M. Matloubi, R. Thomann, V. P. Shastri: Polysaccharide hydrogels with tunable stiffness and provasculogenic properties via α-helix to β-sheet switch in secondary structure, Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 12887–12892.
M. Häckh, M. Müller, S. Lüdeke: Substrate-Dependent Stereospecificity of Tyl-KR1: An Isolated Polyketide Synthase Ketoreductase Domain from Streptomyces fradiae, Chem. Eur. J. 2013, 19, 8922–8928.
2012 M. Pfeifer, S. Lüdeke, P. Fischer: Mid-IR laser-based vibrational optical activity, Proc. SPIE 2012, 8219, 821906.
J. Kulig, R. C. Simon, C. A. Rose, S. M. Husain, M. Häckh, S. Lüdeke, K. Zeitler, W. Kroutil, M. Pohl, D. Rother: Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases, Catal. Sci. Technol. 2012, 2, 1580–1589.
S. M. Husain, M. A. Schätzle, C. Röhr, S. Lüdeke, M. Müller: Biomimetic Asymmetric Synthesis of (R)-GTRI-02 and (3S,4R)-3,4-Dihydroxy-3,4-dihydronaphthalen-1(2H)-ones, Org. Lett. 2012, 14, 3600–3603.
2011 A. C. Chamayou, S. Lüdeke, V. Brecht, T. B. Freedman, L. A. Nafie, C. Janiak: Chirality and Diastereoselection of Δ/Λ-Configured Tetrahedral Zinc Complexes through Enantiopure Schiff Base Complexes: Combined Vibrational Circular Dichroism, Density Functional Theory, 1H NMR, and X-Ray Structural Studies, Inorg. Chem. 2011, 50, 11363–11374.
S. Lüdeke, M. Pfeifer, P. Fischer: Quantum-Cascade Laser-Based Vibrational Circular Dichroism, J. Am. Chem. Soc. 2011, 133, 5704–5707.
2010 C. Dresen, M. Richter, M. Pohl, S. Lüdeke, M. Müller: The Enzymatic Asymmetric Conjugate Umpolung Reaction, Angew. Chem. Int. Ed. 2010, 122, 6600–6603; Angew. Chem. 2010, 122, 6750–6753.
2009 S. Lüdeke, M. Richter, M. Müller: Stereoselective Synthesis of Three Isomers of tert-Butyl 5-Hydroxy-4-Methyl-3-Oxohexanoate through Alcohol Dehydrogenase-Catalyzed Dynamic Kinetic Resolution, Adv. Synth. Catal. 2009, 351, 253–259.
S. Lüdeke, M. Mahalingam, R. Vogel: Rhodopsin Activation Switches in a Native Membrane Environment, Photochem. Photobiol. 2009, 85, 437–441.
2008 R. Vogel, M. Mahalingam, S. Lüdeke, T. Huber, F. Siebert, T. P. Sakmar: Functional Role of the "Ionic Lock"—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors, J. Mol. Biol. 2008, 380, 648–655. (Journal of Molecular Biology Top Cited Article 2008 – 2010)
2006 S. Lüdeke, V. A. Lórenz-Fonfría, F. Siebert, R. Vogel: Time-Resolved Rapid-Scan Fourier Transform Infrared Difference Spectroscopy on a Noncyclic Photosystem: Rhodopsin Photointermediates from Lumi to Meta II, Biopolymers 2006, 83, 159–169.
R. Vogel, S. Lüdeke, F. Siebert, T. P. Sakmar, A. Hirshfeld, M. Sheves: Agonists and Partial Agonists of Rhodopsin: Retinal Polyene Methylation Affects Receptor Activation, Biochemistry 2006, 45, 1640–1652.
2005 S. Lüdeke, M. Beck, E. C. Yan, T. P. Sakmar, F. Siebert, R. Vogel: The Role of Glu181 in the Photoactivation of Rhodopsin, J. Mol. Biol. 2005, 353, 345–356.
R. Vogel, F. Siebert, S. Lüdeke, A. Hirshfeld, M. Sheves: Agonists and Partial Agonists of Rhodopsin: Retinals with Ring Modifications, Biochemistry 2005, 44, 11684–11699.
2004 R. Vogel, S. Lüdeke, I. Radu, F. Siebert, M. Sheves: Photoreactions of Metarhodopsin III, Biochemistry 2004, 43, 10255–10264.
2002 R. Vogel, G. B. Fan, S. Lüdeke, F. Siebert, M. Sheves: A Nonbleachable Rhodopsin Analogue with a Slow Photocycle, J. Biol. Chem. 2002, 277, 40222–40228.
A. Pieroni, V. Janiak, C. M. Dürr, S. Lüdeke, E. Trachsel, M. Heinrich: In Vitro Antioxidant Activity of Non-Cultivated Vegetables of Ethnic Albanians in Southern Italy, Phytother. Res. 2002, 16, 467–473.